Protein Name:
Probable tRNA(His) guanylyltransferase
|
UniprotKB/SwissProt ID: Q9CY52 (Q9CY52)
Gene Name:
Thg1l
Organism: Mus musculus (Mouse)
Function: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
