Protein Name:
Bifunctional purine biosynthesis protein ATIC
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UniprotKB/SwissProt ID: Q9CWJ9 (Q9CWJ9)
Gene Name:
Atic
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:29072452). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:29072452). Also displays cyclohydrolase activity involving the cyclization of FAICAR to inosine monophosphate (IMP). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9CWJ9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
101 |
LDFNLVRVVV C NLYPFVKTVA |
CCCCCEEEEE C CCCCCHHHHH |
1.64% |
21278135
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| 2 |
325 |
FGDFVALSDI C DVPTAKIISR |
CCCCCEEEEE C CCCCCHHHHH |
5.32% |
21278135
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| 3 |
363 |
ILSKKKNGNY C VLQMDQSYKP |
CCCCCEEEEE C CCCCCHHHHH |
2.6% |
20925432
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| 4 |
434 |
AVKYTQSNSV C YAKDGQVIGI |
CCCCCEEEEE C CCCCCHHHHH |
2.47% |
21278135
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