Protein Name:
H/ACA ribonucleoprotein complex subunit 2
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UniprotKB/SwissProt ID: Q9CRB2 (Q9CRB2)
Gene Name:
Nhp2
Organism: Mus musculus (Mouse)
Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Nucleus, Cajal body
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9CRB2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
142 |
HEEYQETYDK C LEEVQALPTP |
CCCCCCCCCH H HHHHCCCCCC |
5.44% |
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| 2 |
18 |
PEESEAQAEG C SEERTYKELL |
CCCCCCCCCH H HHHHCCCCCC |
3.31% |
21278135
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