Protein Name:
Mitochondrial 2-oxoglutarate/malate carrier protein
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UniprotKB/SwissProt ID: Q9CR62 (Q9CR62)
Gene Name:
Slc25a11
Organism: Mus musculus (Mouse)
Function: Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (PubMed:21448454). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9CR62
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
184 |
EEGVPTLWRG C IPTMARAVVV |
CCCCCCCCCC C CCCCCCCCHH |
2.24% |
21278135
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