UniprotKB/SwissProt ID: Q9CR50 (Q9CR50)
Gene Name:
Rchy1
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (By similarity). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (By similarity). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:12654245). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus speckle. Cytoplasm
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