Protein Name:
CDGSH iron-sulfur domain-containing protein 2
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UniprotKB/SwissProt ID: Q9CQB5 (Q9CQB5)
Gene Name:
Cisd2
Organism: Mus musculus (Mouse)
Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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