Protein Name:
STAM-binding protein
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UniprotKB/SwissProt ID: Q9CQ26 (Q9CQ26)
Gene Name:
Stambp
Organism: Mus musculus (Mouse)
Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Membrane. Cytoplasm. Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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