Protein Name:
Glutathione S-transferase 3, mitochondrial
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UniprotKB/SwissProt ID: Q9CPU4 (Q9CPU4)
Gene Name:
Mgst3
Organism: Mus musculus (Mouse)
Function: Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids. Catalyzes the Michael addition reaction of reduced glutathione (GSH) to electrophilic eicosanoids to form GSH adducts, as part of detoxification or metabolic shunt processes. Mediates GSH conjugation to leukotriene A4 to form the sulfidopeptide leukotriene C4. Metabolizes cyclopentenone prostanoids, specifically mediates GSH addition at C9 within the cyclopentenone ring of 15-deoxy-Delta12,14-prostaglandin J2 (15dPGJ2) to form 15dPGJ2-glutathione. L-cysteine cannot substitute for GSH. Catalyzes the reduction of eicosanoid peroxides to yield eicosanoid hydroxides
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9CPU4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
56 |
TDPENGHMFN C IQRAHQNTLE |
CCCCCHHHCE E EEECHHHHHH |
1.59% |
21278135
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