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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Aromatic aminotransferase ISS1

UniprotKB/SwissProt ID: Q9C969 (Q9C969)

Gene Name: ISS1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Coordinates and prevents auxin (IAA) and ethylene biosynthesis, thus regulating auxin homeostasis in young seedlings (PubMed:23377040, PubMed:26163189). Shows aminotransferase activity with methionine; can use the ethylene biosynthetic intermediate L-methionine (L-Met) as an amino donor and the auxin biosynthetic intermediate, indole-3-pyruvic acid (3-IPA) as an amino acceptor to produce L-tryptophan (L-Trp) and 2-oxo-4-methylthiobutyric acid (KMBA) (PubMed:23377040). Can also use tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) as substrates. Regulates tryptophan (Trp) homeostasis and catabolism in mature plants. Also possibly involved in the metabolism of other aromatic amino acids and phenylpropanoid homeostasis (PubMed:26163189)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004839 Aminotransferase_I/II_large
IPR050596 AspAT/PAT-like
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major

The S-nitrosylation sites of Q9C969

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 353 HRHGVVVIPG C ASGSPGYLRV