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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic translation initiation factor 5A-3

UniprotKB/SwissProt ID: Q9C505 (Q9C505)

Gene Name: ELF5A-3

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Involved in supporting growth and plays a regulatory role in the response to sub-lethal osmotic and nutrient stress (PubMed:20492553)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001884 IF5A-like
IPR048670 IF5A-like_N
IPR012340 NA-bd_OB-fold
IPR014722 Rib_uL2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf

The S-nitrosylation sites of Q9C505

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 80 LEDIVPSSHN C DVPHVNRVDY