Protein Name:
(E3-independent) E2 ubiquitin-conjugating enzyme
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UniprotKB/SwissProt ID: Q9C0C9 (Q9C0C9)
Gene Name:
UBE2O
Organism: Homo sapiens (Human)
Function: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR000608
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UBQ-conjugat_E2_core |
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IPR016135
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UBQ-conjugating_enzyme/RWD |
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The S-nitrosylation sites of Q9C0C9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
101 |
GEEEGRGSSG C SEAGGAGHEE |
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| 2 |
1040 |
NPNLYDNGKV C VSLLGTWIGK |
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| 3 |
1099 |
GLQEGYENSR C YNEMALIRVV |
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| 4 |
1288 |
AALLEAGMPE C TEDK------ |
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| 5 |
163 |
VRHMRSTDSQ C GTVIDVNIDC |
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| 6 |
230 |
IILKLSNGAR C SMNTEDGAKL |
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| 7 |
314 |
LKVTWITKSF C PGGTDSVSPP |
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| 8 |
375 |
KIAWECPEKN C AQGEGSMAKK |
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| 9 |
406 |
RIMSCSPDTQ C SRDHSMEDPD |
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| 10 |
598 |
DFVVDKRVQS C PDPAVYGVVQ |
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