UniprotKB/SwissProt ID: Q9C004 (Q9C004)
Gene Name:
SPRY4
Organism: Homo sapiens (Human)
Function: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection, ruffle membrane
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