Protein Name:
FERM domain-containing protein 8
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UniprotKB/SwissProt ID: Q9BZ67 (Q9BZ67)
Gene Name:
FRMD8
Organism: Homo sapiens (Human)
Function: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BZ67
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
246 |
QVQEVSSDGG C EAALGTHYRA |
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