Protein Name:
Inosine triphosphate pyrophosphatase
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UniprotKB/SwissProt ID: Q9BY32 (Q9BY32)
Gene Name:
ITPA
Organism: Homo sapiens (Human)
Function: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BY32
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
116 |
GFEDKSAYAL C TFALSTGDPS |
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| 2 |
146 |
TSGRIVAPRG C QDFGWDPCFQ |
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| 3 |
154 |
RGCQDFGWDP C FQPDGYEQTY |
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| 4 |
33 |
VVQILGDKFP C TLVAQKIDLP |
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| 5 |
57 |
GEPDEISIQK C QEAVRQVQGP |
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