Protein Name:
Oxysterol-binding protein-related protein 11
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UniprotKB/SwissProt ID: Q9BXB4 (Q9BXB4)
Gene Name:
OSBPL11
Organism: Homo sapiens (Human)
Function: Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome membrane. Golgi apparatus, trans-Golgi network membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BXB4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
34 |
TAVTPNKNSS C GGGISSSSSS |
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| 2 |
353 |
INADDEIEDT C DHKEDDLGAV |
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| 3 |
459 |
YNPIIGETFH C SWKMPKSEVA |
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| 4 |
522 |
HPPVSGFYAE C TERKMCVNAH |
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| 5 |
591 |
VELGGKVSVN C AKTGYSASIT |
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| 6 |
629 |
VKHNITNTVV C RVQGEWNSVL |
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