Protein Name:
Intraflagellar transport protein 27 homolog
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UniprotKB/SwissProt ID: Q9BW83 (Q9BW83)
Gene Name:
IFT27
Organism: Homo sapiens (Human)
Function: Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, cilium. Cytoplasm. Cell projection, cilium, flagellum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BW83
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
149 |
RAWALGQGLE C FETSVKEMEN |
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| 2 |
166 |
EMENFEAPFH C LAKQFHQLYR |
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