Protein Name:
Nuclear pore complex protein Nup85
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UniprotKB/SwissProt ID: Q9BW27 (Q9BW27)
Gene Name:
NUP85
Organism: Homo sapiens (Human)
Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). Involved in nephrogenesis (PubMed:30179222)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR011502
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Nucleoporin_Nup85 |
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The S-nitrosylation sites of Q9BW27
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
175 |
HLLDWVRLHV C EVDSLSADVL |
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| 2 |
230 |
ADASPASAGI C RIMGDLMRTM |
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| 3 |
51 |
KKEKSEMVPS C PFIYIIRKDV |
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| 4 |
515 |
RFLRDYCERG C FSDLDLIDNL |
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| 5 |
603 |
SAEQTYELMR C LEDLTSRRPV |
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