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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Spindlin interactor and repressor of chromatin-binding protein

UniprotKB/SwissProt ID: Q9BUA3 (Q9BUA3)

Gene Name: SPINDOC

Organism: Homo sapiens (Human)

Function: Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Chromosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR040647 SPIN-DOC_Znf-C2H2
IPR052675 ZnF_transloc-Spindlin_int

The S-nitrosylation sites of Q9BUA3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 12 ALKAEGAALD C FEVTLKCEEG