Protein Name:
Deoxyhypusine hydroxylase
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UniprotKB/SwissProt ID: Q9BU89 (Q9BU89)
Gene Name:
DOHH
Organism: Homo sapiens (Human)
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16371467, PubMed:16533814, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BU89
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
200 |
AALALAEGLH C GSALFRHEVG |
CCCHHHHHHH H CCCCCCCCCH |
5.76% |
24105792
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| 2 |
242 |
CTENPMVRHE C AEALGAIARP |
CCCHHHHHHH H CCCCCCCCCH |
3.2% |
24105792
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| 3 |
254 |
EALGAIARPA C LAALQAHADD |
CCCHHHHHHH H CCCCCCCCCH |
2.7% |
24105792
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| 4 |
273 |
DDPERVVRES C EVALDMYEHE |
CCCHHHHHHH H CCCCCCCCCH |
4.12% |
24105792
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