Protein Name:
Mini-chromosome maintenance complex-binding protein
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UniprotKB/SwissProt ID: Q9BTE3 (Q9BTE3)
Gene Name:
MCMBP
Organism: Homo sapiens (Human)
Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR019140
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MCM_complex-bd |
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The S-nitrosylation sites of Q9BTE3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
108 |
HFGKYRDVAE C GPQQELDLNS |
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| 2 |
131 |
NTTLERQTFY C VPVPGESTWV |
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| 3 |
200 |
QAGSVGGLQW C GEPKRLETEA |
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| 4 |
239 |
FPLPGEKGPA C LVKVYEDWDC |
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| 5 |
249 |
CLVKVYEDWD C FKVNDILELY |
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| 6 |
287 |
DASALLDPME C TDTAEEQRVH |
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| 7 |
325 |
LQHINPLLPA C LNKEESKTCK |
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| 8 |
396 |
LGKFTVNLSG C PRNSTFTEHL |
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| 9 |
602 |
DLHQLLVVAR C LSLSAGQTTL |
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