Protein Name:
Extended synaptotagmin-1
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UniprotKB/SwissProt ID: Q9BSJ8 (Q9BSJ8)
Gene Name:
ESYT1
Organism: Homo sapiens (Human)
Function: Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BSJ8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
370 |
ALVRLGTQTF C SRVIDEELNP |
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| 2 |
522 |
QESKAVYSTN C PVWEEAFRFF |
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| 3 |
611 |
SEICFPTVPG C PGAWDVDSEN |
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| 4 |
635 |
GSSVDAPPRP C HTTPDSQFGT |
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| 5 |
890 |
LSELLVADQL C LDRWFTLSSG |
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