Protein Name:
Endoplasmic reticulum resident protein 44
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UniprotKB/SwissProt ID: Q9BS26 (Q9BS26)
Gene Name:
ERP44
Organism: Homo sapiens (Human)
Function: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum lumen
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BS26
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
301 |
KGTINFLHAD C DKFRHPLLHI |
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| 2 |
318 |
LLHIQKTPAD C PVIAIDSFRH |
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| 3 |
92 |
ENQVVFARVD C DQHSDIAQRY |
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