UniprotKB/SwissProt ID: Q9BRX8 (Q9BRX8)
Gene Name:
PRXL2A
Organism: Homo sapiens (Human)
Function: Involved in redox regulation of the cell (PubMed:19951071, PubMed:26438880). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Secreted
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