Protein Name:
NAD-capped RNA hydrolase NUDT12
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UniprotKB/SwissProt ID: Q9BQG2 (Q9BQG2)
Gene Name:
NUDT12
Organism: Homo sapiens (Human)
Function: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Peroxisome. Cytoplasmic granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BQG2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
117 |
PWFLTNEVEE C ENYFSKTLLD |
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| 2 |
18 |
LKQEIVTQFH C SAAEGDIAKL |
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| 3 |
247 |
AEEFKQRHEN C YFLHPPMPAL |
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| 4 |
287 |
WHSRYKFCPT C GNATKIEEGG |
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