Protein Name:
Methylosome protein WDR77
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UniprotKB/SwissProt ID: Q9BQA1 (Q9BQA1)
Gene Name:
WDR77
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9BQA1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
186 |
SPHKDSVFLS C SEDNRILLWD |
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| 2 |
26 |
EWNLPPNAPA C MERQLEAARY |
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| 3 |
53 |
LLGASSLSGR C WAGSLWLFKD |
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| 4 |
65 |
AGSLWLFKDP C AAPNEGFCSA |
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