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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor 2
UniprotKB/SwissProt ID: Q9ASR1 (Q9ASR1)

Gene Name: LOS1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Involved in cold responses leading to freezing tolerance via the induction of cold-responsive genes (PubMed:12032361, PubMed:9401119)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR041095 EFG_II
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd
IPR000795 T_Tr_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR005517 Transl_elong_EFG/EF2_IV
The S-nitrosylation sites of Q9ASR1
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 131 ITDGALVVVD C IEGVCVQTET  CCCCCHHHHH H HHHHCCCCCC 
2 286 YEPIKQIIAT C MNDQKDKLWP  CCCCCHHHHH H HHHHCCCCCC 
3 370 DDQYANAIRN C DPNGPLMLYV  CCCCCHHHHH H HHHHCCCCCC  22115780
15734904
4 448 KRQETVEDVP C GNTVAMVGLD  CCCCCHHHHH H HHHHCCCCCC 
5 651 TTGPNMVVDM C KGVQYLNEIK  CCCCCHHHHH H HHHHCCCCCC