Protein Name:
E3 ubiquitin-protein ligase TRIM34A
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UniprotKB/SwissProt ID: Q99PP6 (Q99PP6)
Gene Name:
Trim34a
Organism: Mus musculus (Mouse)
Function: Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Plays an essential role in sustaining the integrity of the inner mucus layer in the colon by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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