UniprotKB/SwissProt ID: Q99P30 (Q99P30)
Gene Name:
Nudt7
Organism: Mus musculus (Mouse)
Function: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:11415433, PubMed:18799520, PubMed:29378847). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (PubMed:11415433). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (PubMed:18799520). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (PubMed:18799520). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (PubMed:18799520). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome
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