UniprotKB/SwissProt ID: Q99NH2 (Q99NH2)
Gene Name:
Pard3
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (PubMed:11839275). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell junction, adherens junction. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane
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