Protein Name:
Splicing factor 3B subunit 1
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UniprotKB/SwissProt ID: Q99NB9 (Q99NB9)
Gene Name:
Sf3b1
Organism: Mus musculus (Mouse)
Function: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (By similarity). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (By similarity). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (By similarity). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (PubMed:26255770)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus speckle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99NB9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1059 |
YVSAREWMRI C FELLELLKAH |
CCCCCCCHHH H HHHHHHHHCH |
1.21% |
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| 2 |
795 |
KKIVLKVVKQ C CGTDGVEANY |
CCCCCCCHHH H HHHHHHHHCH |
1.59% |
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| 3 |
933 |
KRVKPYLPQI C GTVLWRLNNK |
CCCCCCCHHH H HHHHHHHHCH |
2.92% |
20925432
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