Protein Name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial
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UniprotKB/SwissProt ID: Q99NB1 (Q99NB1)
Gene Name:
Acss1
Organism: Mus musculus (Mouse)
Function: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548). Acetate is the preferred substrate (PubMed:11150295, PubMed:16790548). Can also utilize propionate with a much lower affinity (PubMed:11150295). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (PubMed:11150295). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (PubMed:19187775)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99NB1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
144 |
ITYRELLETT C RLANTLKRHG |
CCCHHHHCHH H HHHHHHCCCC |
4.36% |
21278135
|
| 2 |
178 |
SPLAVAAMLA C ARIGAIHTVV |
CCCHHHHCHH H HHHHHHCCCC |
2% |
21278135
|
| 3 |
206 |
SLAGRINDAK C KAVITFNQGL |
CCCHHHHCHH H HHHHHHCCCC |
3.52% |
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| 4 |
235 |
KKIVDEAVKS C PTVQHVLVAH |
CCCHHHHCHH H HHHHHHCCCC |
2.44% |
21278135
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| 5 |
271 |
EQEMAKEAPV C TPESMSSEDM |
CCCHHHHCHH H HHHHHHCCCC |
5.24% |
21278135
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| 6 |
41 |
SRSTATRLPG C VPAAAQPGSY |
CCCHHHHCHH H HHHHHHCCCC |
2.9% |
21278135
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| 7 |
491 |
LEGGDVSGAL C ISQAWPGMAR |
CCCHHHHCHH H HHHHHHCCCC |
2.52% |
21278135
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| 8 |
86 |
WDTPYHTVWD C DFRTGKIGWF |
CCCHHHHCHH H HHHHHHCCCC |
2.9% |
21278135
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