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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Unconventional myosin-VIIb

UniprotKB/SwissProt ID: Q99MZ6 (Q99MZ6)

Gene Name: Myo7b

Organism: Mus musculus (Mouse)

Function: Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, microvillus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR002404 IRS_PTB
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom-like
IPR041793 MyoVII_FERM_C1
IPR041794 MyoVII_FERM_C2
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
IPR051567 Unconventional_Myosin_ATPase

The S-nitrosylation sites of Q99MZ6

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 608 SQTKLGHGTI C QVKAGSQLFK