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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
UniprotKB/SwissProt ID: Q99MR8 (Q99MR8)

Gene Name: Mccc1

Organism: Mus musculus (Mouse)

Function: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR050856 Biotin_carboxylase_complex
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
The S-nitrosylation sites of Q99MR8
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 186 GYHGKDQSDQ C LREHAGKIGY  CHHHHHHHHH C HHHHHCCCEE  4.67% 21278135
2 450 RQSALSKLRY C LHQYNIVGLR  CHHHHHHHHH C HHHHHCCCEE  1.9% 21278135
3 505 SHSTIAKESV C QAALGLILKE  CHHHHHHHHH C HHHHHCCCEE  2.95% 21278135
4 58 VLIANRGEIA C RVIRTAKKMG  CHHHHHHHHH C HHHHHCCCEE  4.36% 21278135
5 591 VLGDLSSEDG C TYLKSSINGV  CHHHHHHHHH C HHHHHCCCEE  3.32% 21278135