Protein Name:
Propionyl-CoA carboxylase beta chain, mitochondrial
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UniprotKB/SwissProt ID: Q99MN9 (Q99MN9)
Gene Name:
Pccb
Organism: Mus musculus (Mouse)
Function: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99MN9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
271 |
RAFDNDVDAL C NLREFFNFLP |
CCHHHHHHHH H HCCCEEHCCC |
4.9% |
21278135
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| 2 |
293 |
SSQDPAPIRE C HDPSDRLVPE |
CCHHHHHHHH H HCCCEEHCCC |
2.95% |
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| 3 |
31 |
CGLGITTRGL C SQPVSVKERI |
CCHHHHHHHH H HCCCEEHCCC |
3.85% |
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| 4 |
367 |
VGNQPNVASG C LDINSSVKGA |
CCHHHHHHHH H HCCCEEHCCC |
2.6% |
21278135
|
| 5 |
518 |
IQPSSTRARI C CDLEVLASKK |
CCHHHHHHHH H HCCCEEHCCC |
0.92% |
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| 6 |
92 |
MESDMFVEHR C ADFGMAADKN |
CCHHHHHHHH H HCCCEEHCCC |
4.61% |
21278135
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