Protein Name:
Beta-adrenergic receptor kinase 1
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UniprotKB/SwissProt ID: Q99MK8 (Q99MK8)
Gene Name:
Grk2
Organism: Mus musculus (Mouse)
Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Postsynapse. Presynapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99MK8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
120 |
DSYIMKELLA C SHPFSKNATE |
CCHHHHHHHH H HHHHHHHHCC |
3.76% |
22178444
17482545
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| 2 |
340 |
HVRISDLGLA C DFSKKRPHAS |
CCHHHHHHHH H HHHHHHHHCC |
6.98% |
22178444
17482545
|
| 3 |
439 |
LQRDVNRRLG C LGRGAQEVKE |
CCHHHHHHHH H HHHHHHHHCC |
4.27% |
22178444
17482545
|
| 4 |
619 |
VEETQIKERK C LLLKIRGGKQ |
CCHHHHHHHH H HHHHHHHHCC |
3.97% |
22178444
17482545
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| 5 |
72 |
KLGYLLFRDF C LNHLEEAKPL |
CCHHHHHHHH H HHHHHHHHCC |
4.33% |
22178444
17482545
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