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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Electron transfer flavoprotein subunit alpha, mitochondrial
UniprotKB/SwissProt ID: Q99LC5 (Q99LC5)

Gene Name: Etfa

Organism: Mus musculus (Mouse)

Function: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR014730 ETF_a/b_N
IPR001308 ETF_a/FixB
IPR033947 ETF_alpha_N
IPR014731 ETF_asu_C
IPR018206 ETF_asu_C_CS
IPR014729 Rossmann-like_a/b/a_fold
The S-nitrosylation sites of Q99LC5
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 109 TQKQFSYTHI C AGASAFGKNL  CCCCCCCHHH H HHHHHHHHHC  1.91% 22178444
21278135
2 155 VRTIYAGNAL C TVKCDEKVKV  CCCCCCCHHH H HHHHHHHHHC  3.69% 21278135
3 159 YAGNALCTVK C DEKVKVFSVR  CCCCCCCHHH H HHHHHHHHHC  7.69%
4 53 AAGRLGGEVS C LVAGTKCDKV  CCCCCCCHHH H HHHHHHHHHC  4.24% 20925432
21278135
5 60 EVSCLVAGTK C DKVVQDLCKV  CCCCCCCHHH H HHHHHHHHHC  6.51% 20925432
6 68 TKCDKVVQDL C KVAGVAKVLV  CCCCCCCHHH H HHHHHHHHHC  4.48% 21278135