Protein Name:
Dehydrogenase/reductase SDR family member 4
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UniprotKB/SwissProt ID: Q99LB2 (Q99LB2)
Gene Name:
Dhrs4
Organism: Mus musculus (Mouse)
Function: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99LB2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
210 |
ELAPKNIRVN C LAPGLIKTRF |
CCCHHHCCCH H HHHHHHHHHH |
2.91% |
21278135
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| 2 |
89 |
GEGLSVTGIV C HVGKAEDREK |
CCCHHHCCCH H HHHHHHHHHH |
1.71% |
21278135
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