Protein Name:
Actin-related protein 3
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UniprotKB/SwissProt ID: Q99JY9 (Q99JY9)
Gene Name:
Actr3
Organism: Mus musculus (Mouse)
Function: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99JY9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
12 |
AGRLPACVVD C GTGYTKLGYA |
CCCCCCEEEE E CCCCCEECCC |
3.38% |
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| 2 |
189 |
PVAEGYVIGS C IKHIPIAGRD |
CCCCCCEEEE E CCCCCEECCC |
3.97% |
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| 3 |
235 |
KAVKERYSYV C PDLVKEFNKY |
CCCCCCEEEE E CCCCCEECCC |
1.32% |
24895380
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| 4 |
34 |
NTEPQFIIPS C IAIKESAKVG |
CCCCCCEEEE E CCCCCEECCC |
1.72% |
21278135
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| 5 |
408 |
KDYEEIGPSI C RHNPVFGVMS |
CCCCCCEEEE E CCCCCEECCC |
4.2% |
24926564
20925432
21278135
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| 6 |
8 |
---MAGRLPA C VVDCGTGYTK |
CCCCCCEEEE E CCCCCEECCC |
2.64% |
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