Protein Name:
G-protein coupled receptor 37-like 1
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UniprotKB/SwissProt ID: Q99JG2 (Q99JG2)
Gene Name:
Gpr37l1
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (PubMed:28795439)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, cilium membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99JG2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
203 |
TKQRLLGDVS C RAVPFMEVSS |
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| 2 |
481 |
SPPLLPLGTP C ---------- |
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