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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytoplasmic tRNA 2-thiolation protein 1

UniprotKB/SwissProt ID: Q99J10 (Q99J10)

Gene Name: Ctu1

Organism: Mus musculus (Mouse)

Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR056369 CTU1-like_ATP-bd
IPR032442 CTU1_C
IPR000541 Ncs6/Tuc1/Ctu1
IPR014729 Rossmann-like_a/b/a_fold
IPR011063 TilS/TtcA_N

The S-nitrosylation sites of Q99J10

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 299 RCGALASHKL C QACALLDGLN