Protein Name:
Methylosome protein WDR77
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UniprotKB/SwissProt ID: Q99J09 (Q99J09)
Gene Name:
Wdr77
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (By similarity). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles (By similarity). Might play a role in transcription regulation (By similarity). The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:19584108) Substrate-recognition component of the DCX(WDR77) complex, which mediates ubiquitination and degradation of Irgm1 in intestinal cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q99J09
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
172 |
SYRAHAGQVT C VAASPHKDSV |
CCCCCCCCCC C CCCCCCCCCC |
1.74% |
21278135
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| 2 |
186 |
SPHKDSVFLS C SEDSRILLWD |
CCCCCCCCCC C CCCCCCCCCC |
5.85% |
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| 3 |
247 |
VSLVDTKNAS C TLSSAVHSQG |
CCCCCCCCCC C CCCCCCCCCC |
4.05% |
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