dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: T-complex protein 1 subunit eta

UniprotKB/SwissProt ID: Q99832 (Q99832)

Gene Name: CCT7

Organism: Homo sapiens (Human)

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:

InterPro ID	Domain Name
IPR012720	Chap_CCT_eta
IPR017998	Chaperone_TCP-1
IPR002194	Chaperonin_TCP-1_CS
IPR002423	Cpn60/GroEL/TCP-1
IPR027409	GroEL-like_apical_dom_sf
IPR027413	GROEL-like_equatorial_sf
IPR027410	TCP-1-like_intermed_sf
IPR053374	TCP-1_chaperonin
IPR054827	thermosome_alpha

The S-nitrosylation sites of Q99832

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	PubMed ID
1	158	KVEQRKLLEK C AMTALSSKLI	CCCCCEEEEE C CCCCCCCHHH	1.98%
2	29	IPQLVSNISA C QVIAEAVRTT	CCCCCEEEEE C CCCCCCCHHH	2.37%
3	310	TQYFADRDMF C AGRVPEEDLK	CCCCCEEEEE C CCCCCCCHHH	2.93%
4	326	EEDLKRTMMA C GGSIQTSVNA	CCCCCEEEEE C CCCCCCCHHH	3.27%
5	345	NALSADVLGR C QVFEETQIGG	CCCCCEEEEE C CCCCCCCHHH	3.72%	37478858
6	364	GGERYNFFTG C PKAKTCTFIL	CCCCCEEEEE C CCCCCCCHHH	2.58%	22178444 19483679 20140087
7	370	FFTGCPKAKT C TFILRGGAEQ	CCCCCEEEEE C CCCCCCCHHH	2.63%	2212679
8	450	KALEIIPRQL C DNAGFDATNI	CCCCCEEEEE C CCCCCCCHHH	2.61%	22178444 19483679 20140087
9	511	NALTAASEAA C LIVSVDETIK	CCCCCEEEEE C CCCCCCCHHH	3.25%

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