UniprotKB/SwissProt ID: Q96T60 (Q96T60)
Gene Name:
PNKP
Organism: Homo sapiens (Human)
Function: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
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