Protein Name:
RUN and FYVE domain-containing protein 1
|
UniprotKB/SwissProt ID: Q96T51 (Q96T51)
Gene Name:
RUFY1
Organism: Homo sapiens (Human)
Function: Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q96T51
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
184 |
FGPLELVEKL C PEASDIATSV |
CCCCCCCCCC C CCCCCCCCCC |
4.19% |
2212679
|
| 2 |
320 |
YVEELNRHLS C TVGDLQTKID |
CCCCCCCCCC C CCCCCCCCCC |
4.5% |
|
| 3 |
351 |
EELSAATDRI C SLQEEQQQLR |
CCCCCCCCCC C CCCCCCCCCC |
3.28% |
|
| 4 |
603 |
QDEKAELQKI C EEQEQALQEM |
CCCCCCCCCC C CCCCCCCCCC |
6.41% |
|
|
