Protein Name:
2-aminoethanethiol dioxygenase
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UniprotKB/SwissProt ID: Q96SZ5 (Q96SZ5)
Gene Name:
ADO
Organism: Homo sapiens (Human)
Function: Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:29752763, PubMed:31273118, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:29752763, PubMed:32601061). Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) (PubMed:31273118, PubMed:32601061)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96SZ5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
183 |
RAEYTEASGP C ILTPHRDNLH |
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| 2 |
239 |
VRPKEASSSA C DLPREVWLLE |
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| 3 |
258 |
LETPQADDFW C EGEPYPGPKV |
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