Protein Name:
Formin-binding protein 1
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UniprotKB/SwissProt ID: Q96RU3 (Q96RU3)
Gene Name:
FNBP1
Organism: Homo sapiens (Human)
Function: May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Membrane, clathrin-coated pit
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96RU3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
511 |
DSQNPPTVNN C AQDRESPDGS |
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| 2 |
555 |
DEEPLPAIGT C KALYTFEGQN |
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| 3 |
609 |
GYVPTSYVEV C LDKNAKDS-- |
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