Protein Name:
Trimethylguanosine synthase
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UniprotKB/SwissProt ID: Q96RS0 (Q96RS0)
Gene Name:
TGS1
Organism: Homo sapiens (Human)
Function: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR019012
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RNA_cap_Gua-N2-MeTrfase |
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IPR029063
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SAM-dependent_MTases_sf |
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The S-nitrosylation sites of Q96RS0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
573 |
LETNNPEPEK C QSVSSAGELE |
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| 2 |
602 |
LLATVPDEQD C VTQEVPDSRQ |
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