Protein Name:
BRCA1-A complex subunit RAP80
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UniprotKB/SwissProt ID: Q96RL1 (Q96RL1)
Gene Name:
UIMC1
Organism: Homo sapiens (Human)
Function: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96RL1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
121 |
RKAIAESLNS C RPSDASATRS |
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| 2 |
298 |
DPNQYTKVIL C QLEVYQKSLK |
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| 3 |
336 |
PRPPSLIQNE C GQGEQASEKN |
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| 4 |
348 |
QGEQASEKNE C ISEDMGDEDK |
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| 5 |
445 |
PESSAEEITV C PETQLSSSET |
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