Protein Name:
Dedicator of cytokinesis protein 7
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UniprotKB/SwissProt ID: Q96N67 (Q96N67)
Gene Name:
DOCK7
Organism: Homo sapiens (Human)
Function: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, axon
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q96N67
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
193 |
IDDTPRGSWA C SIFDLKNSLP |
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| 2 |
1944 |
KNYNLRRFMY C TPFTLDGRAH |
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| 3 |
2125 |
QLYKAVLPVT C HRDSFSRMSL |
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37478858
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| 4 |
457 |
LERTTSGDDA C NLTSFRPATL |
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| 5 |
523 |
ISPAPENPHY C LTPELLQVKL |
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| 6 |
608 |
AMPVIFGKSS C SEFSKEAYTA |
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