UniprotKB/SwissProt ID: Q96MT3 (Q96MT3)
Gene Name:
PRICKLE1
Organism: Homo sapiens (Human)
Function: Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus membrane. Cytoplasm, cytosol
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